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2. The efficacy of modern remineralising therapies containing calcium phosphate in remineralising enamel subsurface lesions

Author

Alotaibi, Shaikhah M. A. M. and Tahmassebi, Jinous

Subjects
618.92
Abstract

Aims: To investigate in vitro the effect of Calcium Phosphate delivering technologies: Tooth Mousse (10% w/v CPP-ACP), MI paste Plus (10% w/v CPP-ACP, 900 ppm F), Clinpro 5000 (Tri-Calcium Phosphate, 5000 ppm F), Clinpro Tooth Crème ( Tri-Calcium Phosphate, 950 ppm F) in the remineralisation of artificial enamel subsurface lesions of bovine teeth and compare it with the effect of 1450 ppm F, 5000 ppm F, and 0 ppm F toothpastes using Quantitative Light-induced Fluorescence (QLF) technology. Materials and Methods: Artificial enamel subsurface lesions were created in bovine enamel slabs (N=182) which were assigned randomly to seven groups; (1) Fluoride-free Toothpaste (negative control), (2) 1450 ppm F toothpaste (positive control), (3) 5000 ppm F toothpaste, (4) 1450 ppm F toothpaste + Tooth Mousse (10% w/v CPP-ACP), (5) 1450 ppm F toothpaste + MI Paste Plus (10% w/v CPP-ACP, 900 ppm F), (6) Clinpro 5000 (Tri-Calcium Phosphate, 5000 ppm F), and (7) Clinpro Tooth Crème ( Tri-Calcium Phosphate, 950 ppm F). All the experimental products were used according to the manufacturer recommendation of dosage. The enamel slabs were cycled for 28 days, QLF images were taken at the baseline and at the endpoint of the experiment. Data analysis was carried out using one-way analysis of variance (One way ANOVA). Results: There were significant improvements in QLF values with all remineralising agents at the end of the study compared with baseline values within each group (P < 0.05). All groups showed a statistically significant improvement in ΔQ and Area of the lesion values compared with negative control (0 ppm fluoride) (P < 0.05). In term of ΔF values measurement, Clinpro Tooth crème was significantly more effective than high fluoride toothpaste (5000 ppm F) (P < 0.05). 5000 ppm fluoride toothpaste was not different significantly to either Clinpro 5000 or the fluoride-free toothpaste (P > 0.05). Conclusion: All group products were significantly more effective as remineralising agents of artificial early enamel subsurface lesions as compared with the negative control 0 ppm F. Calcium Phosphate delivering technologies; CPP-ACP with and without fluoride and Tri-Calcium Phosphate products were as effective as fluoridated toothpastes (1450 ppm F and 5000 ppm F) in remineralising artificial early enamel subsurface lesions. Tooth Mousse was as effective as MI Paste Plus when used in conjunction with 1450 ppm F toothpaste in remineralising artificial early enamel subsurface lesions in bovine teeth assessed using QLF technology.

Published
2018

6. Ketamine administration for acute painful sickle cell crisis: A randomized controlled trial.

Author

Alshahrani, Mohammed S., AlSulaibikh, Amal H., ElTahan, Mohamed R., AlFaraj, Sukayna Z., Asonto, Laila P., AlMulhim, Abdullah A., AlAbbad, Murad F., Almaghraby, Nisreen, AlJumaan, Mohammed A., AlJunaid, Thamir O., Darweesh, Moath N., AlHawaj, Faisal M., Mahmoud, Alaa M., Alossaimi, Bader K., Alotaibi, Shaikhah K., AlMutairi, Talal M., AlSulaiman PharmD, Duaa A., Alfaraj, Dunya, Alhawwas, Reem, and Mbuagbaw, Lawrence

Subjects
DRUG therapy for sickle cell anemia, ARTERIAL occlusions, DRUG efficacy, LENGTH of stay in hospitals, PAIN, PATIENTS, RANDOMIZED controlled trials, COMPARATIVE studies, MORPHINE, PRE-tests & post-tests, HOSPITAL admission & discharge, KETAMINE, BLIND experiment, DESCRIPTIVE statistics, STATISTICAL sampling, ACUTE diseases, LONGITUDINAL method, SYMPTOMS, EVALUATION, ADULTS
Abstract

Objective: The objective was to evaluate the efficacy and safety of single‐dose ketamine infusion in adults with sickle cell disease (SCD) who presented with acute sickle vasoocclusive crisis (VOC). Methods: This study was a parallel‐group, prospective, randomized, double‐blind, pragmatic trial. Participants were randomized to receive a single dose of either ketamine or morphine, infused over 30 min. Primary outcome was mean difference in the numerical pain rating scale (NPRS) score over 2 h. NPRS was recorded every 30 min for a maximum of 180 min and secondary outcomes were cumulative dose of opioids, emergency department (ED) length of stay, hospital admission, change in vital signs, and drug‐related side effects. Authors performed the analysis using intention‐to‐treat principle. Result: A total of 278 adults with SCD and who presented with acute sickle VOC participated in this trial. A total of 138 were allocated to the ketamine group. Mean (±standard deviation [SD]) NPRS scores over 2 h were 5.7 (±2.13) and 5.6 (±1.90) in the ketamine and morphine groups. The ketamine group received significantly lower cumulative doses of morphine during their ED stay (mean ± SD = 4.5 ± 4.6 mg) than of the morphine group (mean ± SD = 8.5 ± 7.55 mg). Both groups had similar rates of hospital admission: 6.3% in the ketamine group had drug‐related side effects compared to 2.2% in the morphine group. Conclusion: Early use of ketamine in adults with VOC resulted in a meaningful reduction in pain scores over a 2‐h period and reduced the cumulative morphine dose in the ED with no significant drug‐related side effects in the ketamine‐treated group. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Multi-dimensional Ratings for Research Paper Recommender Systems: A Qualitative Study

Author

Alotaibi, Shaikhah, Vassileva, Julita, and Largillier, Thomas

Subjects
collaborative filtering, Research paper recommender system, user-centric design, multi-dimensional rating, [INFO] Computer Science [cs]
Abstract

Research paper recommender systems (RSs) aim to alleviate information overload for researchers. Existing approaches using collaborative filtering or hybrid approaches typically allow only one rating criterion (overall liking) for users to evaluate papers. We conducted a focus group qualitative study to explore the most important criteria for rating research papers that can be used to control the paper recommendation by enabling users to set the weight for each criterion. We investigate also the effect of using different rating criteria on the user interface design and how the user can control the weight of the criteria.

Published
2015

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